Anesthesia and Lymphocytes Apoptosis

Ruijin Hospital105 enrolled

Overview

Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

105

Conditions

Anesthesia

Interventions

SevofluraneDRUG

anesthesia was maintained with sevoflurane (end-tidal concentration 1.0-1.5 minimum alveolar concentration)

PropofolDRUG

anesthesia was maintained with propofol (2-4 μg/ml via target-controlled infusion)

combine of sevoflurane and propofolDRUG

anesthesia was maintained with a combine of propofol (1 μg/ml via target-controlled infusion) and sevoflurane (end-tidal concentration 0.7-1.0 minimum alveolar concentration)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * male adults * aged 18-80 yr * undergoing elective OPCAB surgery containing left anterior descending artery bypass Exclusion Criteria: * a previous unusual response to any of the experimental anesthetics * severe cardiac dysrhythmias or ejection fraction below 30% * hemodynamic instability * previous surgical coronary artery repair * anemia, abnormal leukocytes or coagulopathy * severe hypertension * severe hepatic (albumin\<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions * concomitant surgical procedures and psychiatric disorders * Insulin-dependent diabetics

Locations (1)

Ruijin Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

Lymphocyte Count

Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.

Time frame: 1 day after surgery

Secondary Outcomes

Intensive Care Unit Staying Days

Time frame: participants will stay in intensive care unit after surgery, an expected average of 2 days

Data from ClinicalTrials.gov

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