Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct

Inclusion Criteria: * Experiences stroke onset within 2 weeks to 2 months * NIHSS score of \>10-35 * Never received or failed thrombolysis * Evidence of unilateral middle cerebral artery infarct on brain MRI Exclusion Criteria: * Medically unfit (eg. those are unstable haemodynamically despite treatment, with worsening conscious level and with other serious medical co-morbidity) * Evidence of any tumor or other space-occupying lesion on brain MRI * Evidence of hemorrhagic stroke on brain CT or MRI * Experiences transient ischemic attack or lacunar infarct * Has any acute or chronic infections such as Hepatitis B, Hepatitis C and HIV * Is diagnosed with concurrent malignancy or primary hematological disorders * Renal impairment indicated with serum creatinine greater than 200 umol/l or creatinine clearance less than 30 ml/min * Liver impairment indicated with serum aspartate transaminase and serum alanine transaminase greater than 4 times upper limit of the normal range * Any contraindication to stem cell transplantation or bone marrow biopsy * Any co-morbidity which will compromise the ability to obtain adequate stem cells (eg. chronic debilitating diseases, frail patients and patients with known osteoporosis) * Any contraindication to brain MRI (eg. metal implants, pacemaker, joint implants and ocular implants)