Previous some studies suggested the addition of chemotherapy to radiation therapy after surgery may have survival benefit in patients with high risk endometrial cancer. In addition, docetaxel plus cisplatin regimen may have similar efficacy with paclitaxel plus carboplatin which is currently used in most cases. However, docetaxel plus cisplatin may cause less toxicity compared to paclitaxel plus carboplatin. Therefore, the investigators aimed to analyze the efficacy of docetaxel plus cisplatin regimen followed by radiation therapy after surgery in patients with high risk endometrial cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
67
Docetaxel 70mg/m2BSA, q 3 weeks, 3 cycles
Cisplatin 60mg/m2BSA, q 3 weeks, 3 cycles
Pelvic radiation therapy (Extended filed radiation therapy and addition of brachytherapy is allowed)
Asan Medical Center
Seoul, South Korea
RECRUITINGProgression-free survival
Time frame: 2 years after completion of study treatment
Overall survival
Time frame: 2 years after completion of study treatment
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Time frame: Before each chemotherapy, an expected average of 3 weeks
Quality of life
Time frame: 3 months after completion of study treatment
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