A Study on Safety, Pharmacokinetics and Pharmacodynamics of RO5508887 in Healthy Volunteers

Inclusion Criteria: * Healthy male volunteers, 18-45 (Part 1) or 18-65 (Part 2) years of age inclusive; healthy status is defined by absence of evidence of any active or chronic disease * Body Mass Index (BMI) 18 to 30 kg/m2 inclusive * Male subjects must use a barrier method of contraception for the duration of the study and for 30 days after the last dose Exclusion Criteria: * Suspicion of regular consumption of drugs of abuse * Regular smoker (\>5 cigarettes, \>1 pipeful or \>1 cigar per day) * Positive for hepatitis B, hepatitis C or HIV infection * History of hypersensitivity or severe drug reaction * Participation in an investigational drug or device study within three months before the first drug administration