Insulin treatment often causes the blood glucose levels to fall too low. The body usually responds to low blood glucose levels by releasing hormones which act against the insulin to help correct the low blood glucose levels. However, this hormone response can be altered in people with diabetes. Currently there are no therapeutic agents that can be used to improve the recovery from hypoglycemia (low blood sugar). Naltrexone is a tablet used to help people who are addicted to alcohol or morphine-based drugs to remain drug and alcohol-free but it can also affect the levels of the hormones which are released during hypoglycemia. The aim of this study is to determine whether naltrexone can be used to improve and accelerate the recovery from hypoglycemia in patients with type 1 diabetes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
17
Naltrexone 100mg for two administrations.
Naltrexone 50mg for two administrations.
Yale School of Medicine
New Haven, Connecticut, United States
Glucose (mg/dL)
Glucose was measured in the blood throughout the hyperinsulinemic-hypoglycemic clamp study.
Time frame: End of study (up to 240 minutes)
Glucose Infusion Rate (mg/kg.Min)
The glucose infusion rate corresponds to the amount of 20% dextrose given during the hyperinsulinemic-hypoglycemic clamp study, necessary to keep blood glucose levels at the target range (50-55 mg/dL).
Time frame: End of study (up to 240 minutes)
Glucagon (pg/mL)
Glucagon was measured in the blood throughout the hyperinsulinemic-hypoglycemic clamp study.
Time frame: End of study (up to 240 minutes)
Cortisol (ug/dL)
Cortisol was measured in the blood throughout the hyperinsulinemic-hypoglycemic clamp study.
Time frame: End of study (up to 240 minutes)
Epinephrine (pg/mL)
Epinephrine was measured in the blood throughout the hyperinsulinemic-hypoglycemic clamp study.
Time frame: End of study (up to 240 minutes)
Norepinephrine (pg/mL)
Norepinephrine was measured in the blood throughout the hyperinsulinemic-hypoglycemic clamp study.
Time frame: End of study (up to 240 minutes)
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