The purpose of this study is to find the heparinization method, which 1. affect the heparin-protaminsulfate ratio in the best way to achieve haemostasis 2. gives the smallest change in endogenous thrombin potential (ETP)postoperative compared to preoperative (deltaETP) as an indicator for haemostatic activation during cardiac surgery. The hypothesis is that the deltaETP is larger in the Haemochron Signature Elite group than in the Hepcon-group because of the heparinization-method. Therefore there is a potential higher risk for use of bloodproducts postoperatively.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Activated clotting time used for heparinization strategy during cardiag surgery versus blood-heparin concentration
Aalborg Hospital
Aalborg, Aalborg, Denmark
Delta Thrombingeneration
Postoperative versus preoperative thrombingeneration evaluated by Endogenous Thrombin Potential,peak Thrombin level and Lagtime by using a Thromboscope
Time frame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
peroperative heparine/protaminesulphate ratio
Time frame: The timeframe is from the first heparin is given to the neutralization with protamine sulfate, average time 4 hours
Platelet function
Platelet aggregation measured by Multiplate platelet function analyzer
Time frame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
Thromboelastometry
We are looking at the parameters: Clottingtime, Clot formation time and maximum velocity,maximum clot firmness
Time frame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
Standard coagulationtests
Time frame: Timeframe is from Start of surgery to 4 hours after end of surgery, average time 9 hours.
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