NCT01463995 - Prognosis in Neurological Intensive Care Unit Patients (proNICU Cohort) | Crick | Crick

Prognosis in Neurological Intensive Care Unit Patients (proNICU Cohort)

N/ACompletedNCT01463995

Charite University, Berlin, Germany46 enrolled

Overview

This study examines the prognostic properties of immune parameters, clinical scores, electrophysiological tests (eeg, ssep, emg, eng) and functional imaging for the prediction of functional outcome one year after treatment on a neurological intensive care unit.

Study Type

OBSERVATIONAL

Enrollment

46

Conditions

Neurological Diseases

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * severe neurological disease making treatment on a neurological intensive care unit necessary * age ≥ 18 * consent by the patient or the legal representative Exclusion Criteria: * participation in an interventional trial

Locations (1)

Charite University (Center for Stroke Research Berlin CSB & NeuroCure Clinical Research Center NCRC)

Berlin, Germany

Outcomes

Primary Outcomes

Predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset

To evaluate of the predictive properties of immune parameters (IL6, IL10, mHLA-DR) for functional outcome one year after symptom onset

Time frame: one year after symptom onset

Secondary Outcomes

To evaluate of the predictive properties of clinical scores for functional outcome one year after symptom onset

To evaluate of the predictive properties of clinical scores for functional outcome one year after symptom onset

Time frame: one year after symptom onset

To evaluate of the predictive properties of electrophysiological measurements one year after symptom onset

To evaluate of the predictive properties of electrophysiological measurements one year after symptom onset

Time frame: one year after symptom onset

To evaluate of the predictive properties of conventional (DTI) and functional imaging (resting state) one year after symptom onset

To evaluate of the predictive properties of conventional (DTI) and functional imaging (resting state) one year after symptom onset

Time frame: one year after symptom onset

Transcriptome analyses

To perform transcriptome analyses to identify new biomarkers which may predict the one year- neurological outcome

Time frame: one year after symptom onset

Predictive properties of immune parameters in the cerebrovascular fluid for functional outcome one year after symptom onset

To evaluate of the predictive properties of immune parameters in the cerebrovascular fluid for functional outcome one year after symptom onset

Data from ClinicalTrials.gov

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