The purpose of this study is to determine whether the use of pure honey will help in the treatment of radiation induced xerostomia and oral mucositis (symptom management)
Radiation-induced mucositis is a normal acute side effect of radiotherapy treatment. Exposure of ionising radiation to oral, pharyngeal and laryngeal mucosa gives rise to radiation epithelitis towards the second and third weeks of conventional fractionated radiotherapy. Likewise, salivary flow may decrease by approximately 50% during the first week of radiotherapy and upwards of 80% by the seventh week of treatment. Acute radiation-induced xerostomia is associated with inflammatory reaction. The study will include an intervention and a control group, one receiving honey prior and after the radiotherapy and the other group not receiving honey at all.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
72
The patients in the intervention group will receive honey mouthwash 15 minutes before the radiotherapy session, 15 minutes after and 6 hours after the radiotherapy session
Saline rinses 15 minutes before radiotherapy, 15 minutes after, and 6 hours after radiotherapy
Bank of Cyprus Oncology Centre
Nicosia, Nicosia, Cyprus
Change from baseline in Xerostomia grades
Time frame: 1 week, 2 weeks, 3 weeks, 4 weeks
Change from baseline in oral mucositis grades
Time frame: 1 week, 2 weeks, 3 weeks, 4 weeks
Changes in the General satisfaction of comfort
Time frame: 1 week, 2 week, 3 week, 4 week
Change in baseline weight in one month
Time frame: 4 weeks
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