Treating Hispanic Patients Diagnosed With Hepatitis C Using Boceprevir

Inclusion Criteria: To be eligible for this trial, patients must have documentation of the following: * Male or female \> 18 years old * HCV genotype-1 infection * Liver biopsy consistent with Chronic Hepatitis C (CHC) within the last 3 years * No previous treatment with any anti-HCV therapy (approved or investigational) * For women of childbearing potential, a negative urine pregnancy test result documented within 24 hours prior to the first dose of any study drug (BOC, PEG-INF alfa-2b, or ribavirin). Additionally, all female patients of childbearing potential and all males with female partners of childbearing potential must use two forms of effective contraception (combined) during study treatment and for 6 months after treatment. * Willingness to give written informed consent and to participate in and comply with requirements of the study Exclusion Criteria: Patients with any of the following will not be eligible for participation: * Infection with HCV other than genotype 1 * History or other evidence of a medical condition associated with chronic liver disease other than CHC (e.g., hemochromatosis, autoimmune hepatitis, metabolic liver disease, alcoholic liver disease, toxin exposures) * History or other evidence of decompensated liver disease (e.g., coagulopathy, hyperbilirubinemia, hepatic encephalopathy, hypoalbuminemia, ascites, bleeding from esophageal varices) or a Child-Pugh score \> 6 (see Appendix 1) * Infection with hepatitis A virus (HAV), hepatitis B virus (HBV), or HIV as demonstrated by a positive test at screening for anti-HAV immunoglobulin M (IgM) antibodies (Ab), hepatitis B surface antigen, anti-hepatitis B core protein IgM Ab, or anti-HIV antibodies * History of having received IFN, PEG-IFN, ribavirin, viramidine, levovirin, or investigational HCV protease or polymerase inhibitors at any previous time, or any other systemic antiviral therapy with established or perceived activity against HCV within 3 months prior to enrollment. * Pregnant or breastfeeding * Male partners of females who are pregnant or breastfeeding * Hemoglobin concentration \< 12 g/dL in females or \< 13 g/dL in males or any patient with an increased risk for anemia (e.g., thalassemia, sickle cell anemia, spherocytosis, history of gastrointestinal bleeding) or for whom anemia would be medically problematic * Absolute neutrophil count (ANC) \< 1000 cells/mm3 * Platelet count \< 70,000 cells/mm3 * Receipt of stimulating factors such as granulocyte colony stimulating factor (G-CSF), erythropoietin, or other therapeutic agents to elevate hematology parameters to facilitate patient entry into the study * Serum creatinine concentration \> 1.5 times the upper limit of normal (ULN) * History of severe psychiatric disease, including psychosis and/or depression, characterized by a suicide attempt, hospitalization for psychiatric disease, or a period of disability as a result of psychiatric disease * Poorly controlled thyroid dysfunction * History of cardiac disease (e.g., New York Heart Association functional class II, III, or IV, myocardial infarction within the last 6 months, ventricular tachyarrhythmias requiring ongoing treatment, unstable angina, or other significant cardiovascular diseases. In addition, patients with documented or presumed coronary artery disease or cerebrovascular disease should not be enrolled if, in the judgment of the investigator, an acute decrease in hemoglobin by up to 4 g/dL (as may be seen with ribavirin therapy) would not be well tolerated. * History of uncontrolled severe seizure disorder within the last year * Patients treated previously with protease or polymerase inhibitors * Coadministration of drugs that are highly dependent on CYP3A4/5 for clearance, and for which elevated plasma concentrations are associated with serious and/or life-threatening events including those in Appendix 2. * Coadministration with potent CYP3A4/5 inducers, where significantly reduced boceprevir plasma concentrations may be associated with reduced efficacy.