Treatment of APAP Toxicity With IV and Oral NAC 2008-2011

Akron Children's Hospital47 enrolled

Overview

Retrospective chart review of patients who receive N-acetylcysteine for Acetaminophen(APAP) toxicity to assess length of oral vs. IV treatment and the effect of a Clinical Pharmacology and Toxicology division in the management of APAP ingestions.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Acetaminophen Toxicity

Eligibility

Sex: ALLMin age: 1 MonthMax age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Admitted to CHMCA between June 1, 2008 to June 30, 2011 * Qualifying ICD-9 diagnosis code for the following APAP overdose situations: poisoning, accidental, suicide attempt, therapeutic use, assault, and undetermined (965.4, E850.4, E950.0, E935.4, E962.0, E980.0) * Serum APAP concentration above the possible hepatotoxic line on the Rumack-Matthew's nomogram if obtained \> 4 hours post ingestion * Between ages 0-21 years on date of admission * Acute APAP ingestion Exclusion Criteria: * Serum APAP concentrations not actually documented * Did not receive the oral or IV NAC treatment * Preexisting liver disease such as cirrhosis or hepatitis C * Patient \> 21 years of age on the date of admission * Chronic APAP ingestion

Locations (1)

Children's Hospital Medical Center of Akron

Akron, Ohio, United States

Outcomes

Primary Outcomes

Length of NAC treatment in hours

Length of NAC treatment (in hours) for both IV and PO formulations used in patients with APAP toxicity

Time frame: Retrospective data collection for patient's hospital admission, max estimated 5days

Secondary Outcomes

Pharmacology & Toxicology consults

Documenting whether or not a pharmacology \& toxicology consult was obtained during the patient's hospital admission for APAP toxicity

Time frame: Retrospective data collection for length of patient's hospital admission, max estimated 5 days

Data from ClinicalTrials.gov

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