Analgesic Effect of Pregabalin in Patients Undergoing Total Abdominal Hysterectomy

Northwestern University

Overview

Pregabalin will decrease the total amount of opioid required in patients undergoing total abdominal hysterectomy. In addition, pregabalin will decrease the incidence of opioid-related side effects in patients undergoing total abdominal hysterectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Conditions

Pain

Interventions

Placebo administrationDRUG

Administration of placebo

Pregabalin administrationDRUG

Administration of pregabalin

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 64 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA Physical Status 1-2 * Age 18-64 * BMI 18-35 * Scheduled for elective total abdominal hysterectomy (with or without bilateral salpingo-oophorectomy) * Gender: Female * Consent: Obtained Exclusion Criteria: * Patient refusal * Allergy to study medication(s) * Preoperative use of gabapentinoids * Preoperative use of anticonvulsants * Daily use of analgesics * Hepatic disease * Renal insufficiency (Cr \>2.0) * Alcohol or drug abuse * Pregnancy * Language: Non-English speaking * Patient expected to remain intubated after procedure Dropout: * Patient request * Surgeon request * Allergic reaction to pregabalin * Surgical procedure significantly altered from scheduled procedure

Outcomes

Primary Outcomes

total hydromorphone consumption

total hydromorphone consumption 24 hours post operatively

Time frame: 24 hours

Secondary Outcomes

Pain Scores postoperative

Post operative pain scores

Time frame: Post operative period

Data from ClinicalTrials.gov

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