Myfortic, Prograf, and Corticosteroids in de Novo Liver Transplantation

Inclusion Criteria: * Adults \> or equal to age 18 years * Planned to receive tacrolimus and corticosteroid therapy posttransplant * Serum creatinine at transplant \< or equal to 2.5mg/dL * UCSF tumor staging \< 8cm total * Females of childbearing potential must have a negative serum pregnancy test within 7 days prior to the baseline visit and are required to practice a reliable method of contraception for the duration of the study and for no fewer than 6 weeks after completing the study. * Signed informed consent form prior to any research assessment Exclusion Criteria: * Induction therapy * Requiring dialysis at the time of transplant * Organ transplant other than liver * Pregnant or nursing females * Women of childbearing potential not practicing reliable methods of contraception. Reliable methods for contraception include surgical sterilization (hysterectomy, bilateral tubal ligation), double-barrier method (such as condom and diaphragm). To be considered as post-menopausal and not of childbearing potential, female subjects must have experienced 12 consecutive months of amenorrhea. * Require any medications that interfere with metabolism of Myfortic (other than corticosteroids) * Have a known hypersensitivity to mycophenolate sodium, mycophenolic acid, mycophenolate mofetil, or any of its excipients * Participation in a study of investigational drug in the previous 30 days or 5 half-lives of the investigational drug