Laser Iridotomy Versus Surgical Iridectomy in Early Angle Closure

Sun Yat-sen University120 enrolled

Overview

This is a randomized controlled clinical trial to compare laser peripheral iridotomy(LPI) and surgical peripheral iridectomy. Subjects of primary angle closure suspect, primary angle closure will be randomized to undergo LPI or SPI. Subjects are proposed to be followed up for 3 years.

The following will be studied: 1. To evaluate the safety of these two techniques for the treatment of angle closure. 2. To compare the anterior chamber reaction and IOP changes post surgery. 3. TO establish the UBM/ASOCT chamber angle parameters changes pre and post surgery. 4. To assess the development of PAS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

120

Conditions

Intraocular Pressure Changes Peripheral Anterior Synechiae Increasing

Interventions

Surgical IridectomyPROCEDURE

Surgical Iridectomy is now widely used in our clinical.

Laser IridotomyPROCEDURE

alternative choice to surgical iridectomy

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. more than 50 years old 2. Diagnosis of either: Primary angle closure suspects, Primary angle closure in need of laser iridotomy or surgical iridectomy 3. Able to give Informed concent Exclusion Criteria: 1. Ophthalmic diseases other than glaucoma and cataract 2. pseudophakic or aphakic patients 3. inability to attend regular follow-up assessment or to give informed written consent 4. Secondary causes of angle closure e.g. subluxed lens, uveitis, trauma and neovascular glaucoma 5. Participating in another study 6. monocular patients

Locations (1)

ZhongShan Ophthalmic Center

Guangzhou, Guangdong, China

RECRUITING

Outcomes

Primary Outcomes

intraocular pressure

Time frame: 3 years

Secondary Outcomes

Angle assessment parameters

Angle assessment parameters,such as anterior chamber openning distance,are acquired by anterior segment optical coherence tomography.

Time frame: 3 years

Data from ClinicalTrials.gov

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