The Effect of Roux-en-Y Gastric Bypass on Mitochondrial Function in Type 2 Diabetes

Hvidovre University Hospital30 enrolled

Overview

Roux-en-Y gastric bypass (RYGB) surgery induces resolution of type 2 diabetes, often within days after surgery and before significant weight loss. The aim of this study is to investigate whether changes in mitochondrial function contributes to the early improvement of type 2 diabetes after RYGB.

Mitochondrial dysfunction has been linked to development of insulin resistance in the muscle and hence to the pathogenesis of type 2 diabetes. Mitochondrial function can be studied non-invasively by 31 Phosphor Magnetic Resonance spectroscopy (31PMRS). In this study we will investigate changes in mitochondrial function using the combination of 31 PMRS and Near Infra-Red Spectroscopy (NIRS) after gastric bypass.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Type 2 Diabetes Obesity

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients eligible for gastric bypass surgery or cholecystectomy * Verified type 2 diabetes or normal glucose tolerance by OGTT Exclusion Criteria: * Patients unable to fit the dimensions of the MRI-scanner

Locations (1)

Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

RECRUITING

Central Contacts

Kirstine Nyvold Bojsen-Møller, MD

CONTACT

+4538626371 kirstine.bojsen-moeller@hvh.regionh.dk

Sten Madsbad, professor, MD

CONTACT

+4538622291 sten.madsbad@hvh.regionh.dk

Data from ClinicalTrials.gov

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