Drug Interaction Study of Clopidogrel and Rosuvastatin

Inclusion Criteria: * Healthy individuals, male or female, age 18-65 years old, with no current medical conditions or active diagnoses as determined by the study doctor based on history, physical exam and laboratory evaluations * Subjects that take no other medications 2 weeks prior to the study and during the time course of the study including prescription medications, over-the-counter medications (except acetaminophen), dietary supplements, or drugs of abuse * Subjects with a SLCO1B1\*1A genotype * Subjects able to maintain adequate birth control during the study independent of hormonal contraceptive use * Subjects able to abstain from grapefruit, grapefruit juice, orange juice, caffeinated beverages and/or alcoholic beverages from 3 pm the day before the study to completion of that study day. * Participants determined to have normal liver and kidney function as measured at baseline * BMI between 18.5 - 30 kg/m2 * Subjects capable of fasting from food and beverages at least 8 hours prior to medication dosing * Be able to read, speak, and understand English Exclusion Criteria: * Subjects with active medical problems * Subjects on chronic prescription or OTC medications that cannot be stopped 2 weeks prior to and during the study. * Subjects incapable of multiple blood draws (HCT \<30 mg/dL) * Subjects with a history of rhabdomyolysis * Subjects with a history of drug-related myalgias * Subjects with a history or diagnosis of hemorrhagic tendencies or blood dyscrasias * Subjects with a history of GI bleed or peptic ulcer disease * Subjects with a recent history of trauma * Subjects with a recent history of or upcoming plan of surgery * Subjects that smoke tobacco or have ongoing alcohol or illegal drug use * Subjects who are pregnant, lactating, or trying to conceive during the study period * Subjects allergic to rosuvastatin or clopidogrel or any known component of the medications