The study is designed to investigate the effect of repeated dosing of PF-05175157 on the pharmacokinetics of a single dose of Simvastatin in healthy adult subjects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
14
Day 1: Single dose of simvastatin 20 mg Day 8: single dose of simvastatin 20 mg (with PF-05175157)
Days 2-9 inclusive: daily dosing of PF-05175157 200 mg
Pfizer Investigational Site
South Miami, Florida, United States
Area under the plasma concentration curve of simvastatin and simvastatin acid
Time frame: 10 days
Maximum observed plasma concentration of simvastatin and simvastatin acid
Time frame: 10 days
Time at which maximum plasma concentration of simvastatin and simvastatin acid is observed
Time frame: 10 days
If the data permit, area under the plasma concentration curve of simvastatin and simvastatin acid extrapolated to infinite time
Time frame: 10 days
If the data permit, terminal elimination half-life of simvastatin and simvastatin acid
Time frame: 10 days
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