Efficacy and Safety Study in Patients Suffering From Knee Osteoarthritis

Inclusion Criteria: * presenting with uni or bilateral medial and/or lateral femorotibial osteoarthritis of the knee evolving for more than 6 months * patients taking analgesic medications for at least 3 months prior to randomisation and dissatisfied with their current therapy Exclusion Criteria: * isolated symptomatic femoropatellar osteoarthritis * target knee prothesis * having undergone an articular lavage, or an arthroscopy or any surgery on the target knee in the 6 months preceding randomisation, * target knee osteoarthritis with clinical joint effusion at selection and at randomization * body mass index (BMI) greater than or equal to 30, * patient having received any corticosteroid treatment by any administration route (other than inhalers, ocular, auricular route) in the month preceding randomisation, * patient having received intra-articular steroid injection in the target knee within the month preceding randomisation or patient having received intra-articular hyaluronic acid in the target knee in the 6 months preceding randomisation