Safety Study of OPC-12759 Ophthalmic Solution

Inclusion Criteria: * BMI : {body weight (kg) / \[height (m)\] 2 } must be 17.6 or greater, and less than 26.4 kg/m2 Exclusion Criteria: 1. Presence of ocular disorder 2. Intraocular pressure of 21mmHg or higher 3. Corrected visual acuity of less than 1.0 4. Dysfunction of nasolacrimal duct or history of surgery related to nasolacrimal duct or eye lid which affects the nasolacrimal outflow 5. History of refractive surgery 6. History of other ocular surgeries within 12 months 7. Those who cannot discontinue the use of contact lenses from the 1st dose to 5-hour-post-dose