Effect of Carum Carvi on Thyroid Hormones and TSH Level

Mashhad University of Medical Sciences40 enrolled

Overview

Carum Carvi has been frequently used in traditional medicine for a variety of disease ranging from dyspepsia to Alzheimer's disease.We observed high TSH levels in few patients with thyroid cancer who receiving Carum Carvi despite being on suppressive dose of levothyroxin. TSH level returned to normal after discontinuation of the Carum carvi. This observation led to a pilot study for evaluation of the effect of carum carvi on thyroid function.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Thyroid Cancer Patients

Interventions

Carum CraviDRUG

40mg/kg of body weight

PlaceboDRUG

Placebo

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18-65 * Hypothyroid patients under treatment with levothyroxin * Normal euthyroid patients with no goiter Exclusion Criteria: * Pregnancy or lactation * Severe lung or gasterointestinal disease * Heart failure or renal failure

Locations (1)

Nuclear Medicine Department, Ghaem Hospital

Mashhad, Iran

RECRUITING

Outcomes

Primary Outcomes

Change of Thyroid and thyrotropin values from baseline at 2 and 6 weeks

TSH, Free T4, Free T3, T4RIA and T3RIA

Time frame: 0-2-6 Weeks

Secondary Outcomes

Change of hypothyroidism index from baseline at 2 and 6 weeks

Hypothyroidism Index

Time frame: 0,2 and 6 weeks

Central Contacts

Seyed Rasoul Zakavi, MD,IBNM

CONTACT

+98-511-8022729 zakavir@mums.ac.ir

Zohre Mousavi, MD, IBE

CONTACT

+98-8599359

Data from ClinicalTrials.gov

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