MRA/fMRI Study of Spontaneous Migraine

Glostrup University Hospital, Copenhagen

Overview

The purpose of this study is to examine migraineurs during spontaneous migraine attacks without aura, using high resolution magnetic resonance imaging (MRI), to study following: * Changes in resting state blood-oxygenation-level-dependent-signal (BOLD-signal) using functional MRI (fMRI). * Changes in circumferences of intra- and extracranial arteries using MR-angiography (MRA). * Changes in regional and global cerebral blood flow (CBF) using the arterial spin labeling (ASL) method. Moreover to perform diffusion tensor imaging (DTI) scans during spontaneous migraine attacks. The migraine specific drug sumatriptan will be given to relieve pain and the effect will be registered using MRA and fMRI if possible.

Study Type

OBSERVATIONAL

Conditions

Headache Versus Non-headache Day

Interventions

Headache day versus non-headache dayBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Migraine without aura according to IHS criteria. Exclusion Criteria: * Other primary headaches. * Tension-type headache more than 5 days/month. * Use of anti-pain medication before the scanning on the examination day. * Pregnant or nursing women. * Contraindication for MR scan. * Anamnestic or clinical signs of cardiovascular or cerebrovascular disease, unregulated psychiatric disease or drug misuse. * Other clinical conditions assessed by the examining doctor.

Locations (1)

Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen

Glostrup Municipality, Denmark

RECRUITING

Central Contacts

Faisal Amin, MD, PhD student

CONTACT

+4538633066 famoam01@regionh.dk

Data from ClinicalTrials.gov

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