Effects of Different Early Intensive Therapies on Long-term β-cell Function

Inclusion Criteria: * newly diagnosed type 2 diabetes * fasting blood glucose (FBG) level ranging from 7.0～16.7 mmol/L * body mass index (BMI) ranging from21～35kg/m2 * Antihyperglycaemic and antihyperlipidemic medication-naive patients Exclusion Criteria: * having any severe acute or chronic diabetic complications * renal dysfunction, blood creatinine≥150µmol/L * blood aminotransferase level rising up(more than 2 times of the upper normal limit of ALT) * • Any severe cardiac disease including congestive cardiac failure, unstable angina or myocardial infarct in 12 months * chronic or acute pancreatic disease * severe systematic diseases or malignant tumor * female patients incline to be pregnant * being treated with corticosteroid, immunosuppressing drugs or cytotoxic drugs * poor compliance