The purpose of this study is to examine and compare the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide (VIP) on intracranial arteries and neuronal activity in patients with migraine without aura using a high resolution magnetic resonance imaging (MRI), including MR angiography (MRA) and functional MRI (fMRI). MRA will be used to detect changes in intracranial artery circumferences before and after PACAP38 and VIP. fMRI will be used oo detect changes in blood-oxygenation-level-dependent-signal (BOLD-signal). PACAP38 but not VIP induces migraine like attacks in migraine patients. The migraine specific drug sumatriptan will be given to relieve pain and the effect will also be registered using MRA and fMRI.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
Enrollment
24
10 pmol/kg/min over 20 mins
8 pmol/kg/min over 20 mins
Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen
Glostrup Municipality, Denmark
Comparison between PACAP38 and VIP induced changes in intracranial artery circumference before and after infusions
Time frame: Baseline, 20 minutes, 2 hours and 5 hours
Headache scores
hospital and post hospital phase
Time frame: 24 hours
Comparison between PACAP38 and VIP induced changes in BOLD response
Time frame: 5 hours
Change in intracranial artery circumference before and after injection of sumatriptan
Time frame: 5 hours
Comparison between PACAP38 and VIP induced changes in brain structure
Time frame: 5 hours
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