Effects of HBO Therapy on Muscular Insulin Resistence in Type 2 Diabetes

German Diabetes Center30 enrolled

Overview

Hyperbaric oxygen therapy (HBO) is applied for several diseases. The effect on insulin sensitivity is yet unknown. Hypothesis: HBO therapy improves insulin sensitivity in patients.

HBO therapy is applied to improve wound healing in diabetic patients with foot ulcera. However, it might induce oxidative stress as well as improve antioxidative capacity. The effects on insulin sensitivity in humans and will be tested in the study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Obesity Non-insulin-dependent Diabetes Mellitus

Interventions

HBO therapyPROCEDURE

Effect of 2 hrs HBO therapy on muscular insulin sensitivity and resistance in obesity and type 2 diabetes mellitus

Hyperbaric room airPROCEDURE

Effect of 2 hrs hyperbaric room air on muscular insulin sensitivity and resistance in obesity and type 2 diabetes mellitus

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged ≥ 30 years- ≤ 70 years * Balanced sex (50: 50) * BMI 20- 25 kg/m 2 normal- weight group * BMI 35- 39,9 kg/m 2 (Obese typ II) Exclusion Criteria: * Acute illness 2 weeks before start of examination * Autoimmune or Immune disorder deseases (Leukozyten \< 5000/µl * Renal insufficiency (Kreatin \> 1,5 mg/dl) * Heart disease, condition after heart attack * Anemia (Hb \<12g/l, contolled before every day of eximination) or blood donations 4weeks before eximinatin. * Participation in another trial within the last 2 weeks * Pharmacological- immuno therapy (Cortisol, Antihistaminika, ASS) * Thyroid disorders * Glitazone or Insulin- Therapy * Pragnancy, Lactation, Menstruation * Smoking cigaretts, Alcohol- and drug abuse * Psychiatric disorders * Risk for/ or diagnosed HIV/ AIDS or Hepatitis B/C * Liver disease, which are not caused by non- alcoholic steato- hepatitis * Working on night shifts or irregular rhythem of night- day * Impaired wound healing or clotting disorders * Allergic reaction to local anesthetics * Malignant cancer

Locations (1)

German Diabetes Center

Düsseldorf, Germany

Outcomes

Primary Outcomes

Skeletal muscle insulin sensitivity

Determination of the influence of 2 hours hyperoxygenation on insulin sensitivity redox balance and lipid metabolites of skeletal muscle in patients with T2DM

Time frame: 2 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.