Animal, in vitro and small-scale studies have suggested that creatine supplementation may augment bone mass. This clinical trial aims to investigate the effects of a 2-year creatine supplementation protocol on bone mass in postmenopausal women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
200
The CR group will receive either 1g or 3g of Cr monohydrate (Creapure®) per day throughout the trial. The dose of creatine will be formulated in a tablet.
The placebo group will be given the same dose of dextrose formulated in a tablet to be consumed under the same conditions. The two types of tablets will not be distinguishable from each other having the same appearance, taste and smell.
University of Sao Paulo - School of Medicine
São Paulo, São Paulo, Brazil
RECRUITINGbone mineral density (BMD)
Time frame: 12 and 24 months
bone markers
will include CTX and P1NP
Time frame: 12 and 24 months
history of falls
Time frame: 24 months
bone microarchitecture
Time frame: 12 and 24 months
muscle function
Time frame: 12 and 24 months
lean mass
Time frame: 12 and 24 months
laboratory parameters
Time frame: 12 and 24 months
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