Urinary 8-isoprostane is Elevated in Acute Childhood Asthma

Stony Brook University52 enrolled

Overview

Oxidative stress is seen in children with asthma, but is hard to measure. The investigators exploring the utility of using a commercially available assay to measure oxidative stress in the urine in asthmatics. Additionally, the investigators will attempt to prove that oxidative stress is higher in children with acute asthma compared to those with stable asthma and that this stress is also higher in children with more severe clinical asthma exacerbations compared to less severe ones.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Childhood Asthma Oxidative Stress

Eligibility

Sex: ALLMin age: 4 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Group 1 1. Patients aged 4-18 years 2. Known stable asthmatics on no medications or with no medication changes in 3 weeks prior to enrollment 3. No asthma hospitalizations in past 3 months 4. Parent available to consent Group 2 1. Patients aged 4-18 2. Known asthmatic, admitted to Stony Brook University Hospital for status asthmaticus 3. Parent available to consent Exclusion Criteria: 1. Any child with documented fever within 24 hours of study entry 2. Any child with a known current history of tracheo- or bronchomalacia 3. Any child with known clinical or laboratory evidence of shock (see below) 4. Any child with history of documented immunodeficiency, rheumatologic disease, cystic fibrosis, or renal dysfunction (see below) 5. Any child with a current or recent (less than 1 year) history of tracheostomy 6. Any child with a known genetic abnormality 7. Any pregnant child 8. Any child with a history of autism 9. Any child whose parent/caregiver is unable to give informed consent

Locations (1)

Long Island Children's Hospital at Stony Brook

Stony Brook, New York, United States

Outcomes

Primary Outcomes

We expect to see increased urinary 8-isoprostane in acute pediatric asthmatics

Time frame: Urinary 8-isoprostane levels were measured at the end of subject recruitment

Secondary Outcomes

We expect urinary 8-isoprostane levels to be higher with increased pediatric asthma severity.

Time frame: This was calculated at the end of patient recruitment, after urinary 8-isoprostane levels were obtained

Data from ClinicalTrials.gov

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