Insulin resistance is often complicated with hypertension. AGE and inflammation play important roles in insulin resistance. Some studies reported that pioglitazone, insulin sensitizer, is effective for patients with insulin resistance, however, the mechanisms are still unclear. The aim of this study to evaluate the effect of pioglitazone compared with glimepiride on AGE, inflammatory cytokines and cardiac markers (BNP and echo) in hypertensive patients during oral glucose tolerance test.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
16
pioglitazone (15mg) once a day for 24 weeks
Tottori University Hospital
Yonago, Japan
advanced glycation end-product (AGE)
Time frame: 24 weeks
inflammatory cytokines (TNF-alfa, IL-6 and MCP-1)
Time frame: 24 weeks
cardiac function (echo and BNP)
Time frame: 24 weeks
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