Autologous Endometrial Coculture (AECCT)

Weill Medical College of Cornell University20 enrolled

Overview

The purpose of this study is to determine if the use of Autologous Endometrial Coculture (AECC) in young in vitro fertilization (IVF) patients with poor ovarian reserve improves pregnancy outcome.

Young women with poor ovarian reserve are commonly given a poor prognosis for IVF success. Standard culture media for fertilizing oocytes (unfertilized eggs) is commonly used in IVF which closely resembles tubal fluid. Efforts to create optimal culture conditions for fertilization of human embryos for women with poor quality embryos and/or repeated implantation failures have been developed at our center by using AECC. AECC involves placing a patient's fertilized eggs on top of a layer of cells from her own uterine lining, creating a more natural environment for embryo development and maximizing the chance for IVF pregnancy. The investigators will prospectively randomize young patients (≤ age 38 years) poor ovarian reserve to AECC or no AECC with standard culture media to study pregnancy outcome.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

AECC (Autologous endometrial coculture)PROCEDURE

endometrial biopsy with autologous endometrial coculture

no endometrial biopsy or Autologous endometrial coculture (AECC) performedOTHER

routine procedures with out biopsy

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy women undergoing IVF at CRMI * Age ≤ 38 years * Poor ovarian reserve with antral follicle count less than 6 follicles, cycle day 2/3 FSH \> 12 ng/ml, AMH \< 0.5 ng/ml Exclusion Criteria: * Healthy women undergoing IVF with male factor, severe endometriosis, or tubal factor infertility * Donor patients * Contraindications for the use of gonadotropins (i.e. pregnancy, lactation, undiagnosed vaginal bleeding or ovarian cysts) * Recent or current medical conditions where the patient is not medically stable to undergo stimulation or egg retrieval, HIV infection, diabetes, cardiovascular disease, gastrointestinal, hepatic disease, renal or pulmonary disease. * Any patient who is not a candidate for IVF

Locations (1)

Center for Reproducutve Medicine; Weill Cornell Medical College

New York, New York, United States

Outcomes

Primary Outcomes

Pregnancy outcome

Time frame: 1 month

Secondary Outcomes

Embryo quality

Time frame: 1 month

Data from ClinicalTrials.gov

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