2940nm Er:YAG Laser Versus Benzoyl Peroxide Gel for the Treatment of Inflammatory Acne

Chulalongkorn University25 enrolled

Overview

Acne is one of the most common conditions that patients seek for help in dermatological clinic. Nowadays, conventional treatment including topical agents(retinoids, antibiotics ,antiseptics and keratolytic agents) and systemic agents( antibiotics and retinoids) give a satisfying result but not to every patient. Some patients are not well respond to conventional therapy while some patients are unable to tolerate side effects of the treatments. Therefore, interventions to reduce acne are vigorously experimented . Lights and lasers including intense pulsed light, pulsed dye laser with or without photosensitizer and infrared lasers have been found to be useful in treating active inflammatory acne. Although,pain ,downtime and poor response of comedonal acne are limitations of those lights and lasers therapy. 2940 nm Erbium:YAG laser which has both resurfacing and photothermal effects is our laser of interest to seek for its efficacy in the treatment of inflammatory acne.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Acne Vulgaris

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 year-old to 45 year-old * Mild to moderate severity of acne vulgaris with at least 5 active inflammatory acne lesions on each side of the face and less than 25% difference in lesion count between each side of face * Fitzpatrick skin phototype I-IV Exclusion Criteria: * History or clinical presentation of hypertrophic scar or keloid * Photoaggravated skin diseases i.e. systemic lupus erythematosus, polymorphous light eruption, solar urticaria * Oral isotretinoin taken within the last 6 months prior to enrollment * Topical retinoid within 4 weeks prior to enrollment * Systemic acne therapies (oral antibiotics) within 4 week prior to enrollment

Outcomes

Primary Outcomes

percentage change from baseline of inflammatory acne lesion count at 6 week after 1st 2940nm Er:YAG laser treatment

% change from baseline = (NV- NB)/NB x 100% NV = number of lesion at each visit NB = number of lesion at baseline

Time frame: 6 week

Secondary Outcomes

Safety

Safety profile of 2940nm Er:YAG laser for the treatment of inflammatory acne including; * Visual analogue scale of pain score * Adverse events(AEs) include types of AEs(erythema, pain/burning sensation, dryness/excessive scaling, pigmentary change), timing, intenstity, outcome and action taking regarding to study procedure particular subject.

Time frame: week0,2,4

Photographic clinical improvement

Photographic clinical improvement of acne, acne scar, erythema, hyperpigmentation and overall improvement by blinded dermatologists using quartile grading system comparing baseline and each clinical visit (week 2,4,6 and 10)

Time frame: week 2,4,6 and 10

Patient satisfaction

Self evaluation of patient satisfaction

Time frame: week 6