Changes in Brain Structure Related to Systemic Chemotherapy Treatment: A Prospective Study in Individuals Diagnosed With Non-small Cell Lung Cancer Utilizing High-resolution Structural Magnetic Resonance Imaging

Inclusion Criteria: * Patients between the ages of 18 and 80 years old * As per self report and/or medical record female patients are either postmenopausal or not able to become pregnant * Patients with biopsy proven or suspected non-small cell lung cancer planned to undergo induction chemotherapy and surgery, OR with biopsy proven or suspected non-small cell lung cancer planned to undergo immediate surgical resection * No clinical/neurological symptoms suggestive of brain metastases by attending's judgment as documented in the medical record and/or correspondence with the research team * In the judgement of the consenting professional, patient is able to understand English, through verbal and written communication * Patient is able to undergo MRI scanning (verified with pre-MRI Safety Screening form (Appendix A) used in MSKCC MRI Centers) completed at screening and again prior to having the MRI. Exclusion Criteria: * Patients with history of significant neurological diagnoses including stroke, tumor, dementia, epilepsy, or multiple sclerosis as indicated by medical records and/or self report * History of head injury with evidence of brain injury or loss of consciousness for \> 60 minutes as per EMR or self-report * No prior treatment with chemotherapy * Participant has dentures, body jewelry or wig that they are unable to remove as per self-report * Patient reports that he/she cannot undergo MRI scanning without significant distress or discomfort * Significant psychiatric or cognitive disturbance sufficient, in the investigator's judgment, to preclude providing informed consent or participating in the study (i.e., schizophrenia).