The relationship between cytomegalovirus infection and recurrence of hepatitis C in liver transplant recipients remains controversial. Although some studies (Teixeira et al., 2000; Singh et al., 2005)have not found an association between recurrence of hepatitis C and CMV infection, studies such as Rosen et al. show that 50% of patients with CMV infection suffered cirrhosis durig follow-up period, while between not-infected patients the rate was 11%. To clarify this question, a non-interventional study will be carried out in order to assess if CMV replication is a risk factor for graft dysfunction in liver transplant recipients.
Study Type
OBSERVATIONAL
Enrollment
179
Complejo Hospitalario Universitario de Santiago
Santiago de Compostela, A Coruña, Spain
Hospital Vall d'Hebron
Barcelona, Barcelona, Spain
Hospital de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain
Hospital Reina Sofía
Córdoba, Córdoba, Spain
Hospital General Universitario Gregorio Marañón
Madrid, Madrid, Spain
Hospital Ramón y Cajal
Madrid, Madrid, Spain
Hospital 12 de Octubre
Madrid, Madrid, Spain
Hospital Universitario Carlos Haya
Málaga, Málaga, Spain
Clínica Universitaria de Navarra
Pamplona, Navarre, Spain
Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, Spain
...and 3 more locations
Effect of CMV replication over hepatitis C recurrence
viral charge of HCV will be assessed 48 weeks after transplantation
Time frame: 48 weeks after transplantation
Effect of CMV replication over fibrosis in graft after Hepatitis C recurrence after transplantation
Time frame: 1 year
Effect of CMV recurrence over graft and patient survival
Time frame: 1 year
Relationship between viral charge of CMV and HCV during study period
Time frame: 1 year
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