The purpose of this study is to determine if interruption in gastric-adipose tissue axis signaling contributes to early improvements in oxidative stress, insulin sensitivity, and inflammation, and to determine if interruption of the stomach in RYGB results in reduction of plasma acylated ghrelin (AG) and in an altered acylated ghrelin:unacylated ghrelin (AG:UAG) ratio which may contribute to decreased oxidative stress and improved insulin sensitivity.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
49
0.5-1 pmol/kg.min of human ghrelin administered by IV two times
standard very low calorie diet that is prescribed for all RYGB patients after their operation
Insulin and glucose infusions to measure glucose kinetics.
Vanderbilt University Medical Center
Nashville, Tennessee, United States
change in glucose disposal rate
Glucose disposal rate is a sensitive laboratory procedure for determining how your body uses sugar (called insulin sensitivity).
Time frame: baseline and 1 week
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