The purpose of this study is to analyse the effect of probiotic supplement on symptoms of irritable bowel syndrome.
The aim of the intervention is to analyse the effect of a probiotic supplement in a dose-responsive set up on symptoms of irritable bowel syndrome (IBS). Fulfillment of Rome III criteria will be used as inclusion criterion. Subjective assessment of bowel symptoms, IBS-related quality of life and adequate relief will be assessed as outcome measures.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
149
A single strain probiotic supplement given at two doses
Herttoniemi Hospital
Helsinki, Helsinki, Finland
Change in functional bowel symptoms
Validated questionnaire
Time frame: 0 weeks, 6 weeks, 12 weeks
Change in quality of life
Validated questionnaire
Time frame: 0 weeks, 6 weeks, 12 weeks
Adequate relief
Weekly question
Time frame: Weekly over 3 month intervention
Change in faecal microbiota
Quantification of selected microbes and the intervention strain from faecal samples
Time frame: 0 weeks, 6 weeks, 12 weeks
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