Strong Women Study

Green Beat44 enrolled

Overview

The investigators investigate the impact of an encapsulated fruit, berry and vegetable juice powder concentrate on oxidative stress, inflammation and blood flow before and post exercise in overweight, middle-aged, women. Main hypotheses (H1): * The nutraceutical has an impact on oxidative stress reduction. * The nutraceutical has an impact on inflammation. * The nutraceutical has an impact on blood flow and microcirculation. * Walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers. * Walking exercise for 30 minutes has an impact on blood flow and microcirculation * The combination of nutraceutical supplementation + walking exercise for 30 minutes has an impact on oxidative stress- and inflammation markers, and on blood flow/microcirculation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Oxidative Stress Inflammation

Interventions

Eligibility

Sex: FEMALEMin age: 35 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women * BMI \> 27 * praemenopausal * non smokers * eligibility for exercise * 4wk wash out Exclusion Criteria: * male * all people not matching this age group * BMI \> 40 and \< 27 * peri- or postmenopausal women * smokers * all women taking dietary supplements * all women that fail in ergometric exercise eligibility testing, refering to the standards in sports medicine (e.g.: significant ST-decrease or increase, blood pressure \> 240 mmHg, tachycardia, polymorphic extrasystolia, cyanosis, bradyarrhythmia..) * Diabetics * osteoporosis or osteopenia

Outcomes

Primary Outcomes

Carbonyl groups on protein, oxidized LDL, Malondialdehyde, TNF-alpha, IL-6, Trombelastometry and peripheral microcirculation

Carbonyl groups on protein as indicators of protein oxidation; oxidized LDL, Malondialdehyde as indicators of Lipidoxidation; TNF-alpha, IL-6 as indicators of inflammation; Trombelastometry: clotting time, thrombocyte ahesion, trombocyte aggregation from whole blood as indicators for blood flow and hemostasis; Peripheral microcirculation in subcutis as indicator for blood flow in peripheral subcutis.

Time frame: 6 months