Respiratory Complications After Laparoscopic Surgery

Herlev Hospital60 enrolled

Overview

The purpose of this study is to describe the magnitude of respiratory complications after laparoscopic hysterectomy and cholecystectomy.

The purpose of this study is to describe change in pulmonary function and incidence of respiratory complications after laparoscopic surgery. The investigators will include 60 women scheduled for laparoscopic hysterectomy or cholecystectomy. The investigators will measure the pulmonary function by different methods during and for 2 hours after surgery. Moreover, the incidence of respiratory complications including pneumonia, respiratory failure and radiologically verified atelectasis will be registered.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Atelectasis Respiratory Insufficiency Pneumonia

Eligibility

Sex: FEMALEMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women * \> 45 years old * Scheduled for laparoscopic cholecystectomy or laparoscopic hysterectomy Exclusion Criteria: * Weight \< 50 kg * Pregnant or nursing * Cardiac failure * Renal failure * Inability to breath through a facial mask * Inability to give informed consent * Inability to keep arterial oxygen saturation above 90% without supplemental oxygen

Locations (2)

Department of Anesthesia, Herlev Hospital

Herlev, Denmark

Department of Anesthesia, Hillerød Hospital

Hillerød, Denmark

Outcomes

Primary Outcomes

Arterial oxygen tension 2 hours after surgery

Change in arterial oxygen tension 2 hours after surgery

Time frame: 2 hours after end of surgery

Secondary Outcomes

Oxygenation index 2 hours after surgery

Change in oxygenation index (PaO2/FiO2) 2 hours after surgery

Time frame: 2 hours after end of surgery

FEV1 and FVC 2 hours after surgery

Change in FEV1 and FVC 2 hours after surgery

Time frame: 2 hours after end of surgery

Pulmonary shunt 2 hours after surgery

Change in pulmonary shunt 2 hours after surgery

Time frame: 2 hours after end of surgery

Ventilation-perfusion ratio 2 hours after surgery

Change in ventilation-perfusion ratio from baseline to 2 hours after surgery

Time frame: 2 hours after end of surgery

Arterial oxygen saturation 2 hours after surgery

Change in arterial oxygen saturation 2 hours after surgery

Time frame: 2 hours after surgery

Respiratory frequency 2 hours after surgery

Change in respiratory frequency 2 hours after surgery

Time frame: 2 hours after surgery

Oxygen supplement at discharge from the postanesthesia care unit

The proportion of patients who received oxygen supplement at discharge from the postanesthesia care unit in order keep arterial oxygen saturation above 93%

Data from ClinicalTrials.gov

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Time frame: At discharge from the postanesthesia care unit, which will be approximately 2 hours after surgery

Connection between pulmonary shunt and need for oxygen supplement

The connection between pulmonary shunt 2 hours after surgery and need for oxygen supplement at discharge from the postanesthesia department in order to keep peripheral oxygen saturation above 93%.

Time frame: 2 hours postoperatively and at discharge from the postanesthesia care unit

FEV1 and FVC 24 hours after surgery

Change in FEV1 and FVC 24 hours after surgery

Time frame: 24 hours after surgery

Pulmonary shunt 24 hours after surgery

Change in pulmonary shunt 24 hours after surgery

Time frame: 24 hours after surgery

Ventilation-perfusion ratio 24 hours after surgery

Change in ventilation-perfusion ratio 24 hours after surgery

Time frame: 24 hours after surgery

Arterial oxygen saturation 24 hours after surgery

Change in arterial oxygen saturation 24 hours after surgery

Time frame: 24 hours after surgery

Respiratory frequency 24 hours after surgery

Change in respiratory frequency 24 hours after surgery

Time frame: 24 hours after surgery

Length of stay

Length of stay at the hospital