Safety Study in Adolescent and Adult Patients With Asthma

Inclusion Criteria: * Only subjects who have successfully completed the E004-C study within the last 135 days or those who are actively enrolled in the current study E004-C at the time of the study extension initiation * Male and female asthma patients aged 12 - 75 years * Patients with documented asthma, requiring inhaled epinephrine or beta 2-agonist treatment * No significant changes in asthma therapy and no asthma-related hospitalization or emergency visits, within 4 weeks prior to Screening * Demonstrating satisfactory techniques in the use of metered-dose inhaler and a hand held peak expiratory flow meter * Female patients of child-bearing potential must be non-pregnant and non-lactating at Screening and throughout the study, and must use an acceptable method of contraception during the study Exclusion Criteria: * A smoking history of 10-pack years, or having smoked within 12 months of screening * Any current or past medical conditions that, per investigator discretion, might significantly affect responses to the study drugs, other than asthma * Concurrent clinically significant diseases * Known intolerance or hypersensitivity to any component of the study drugs * Recent infection of the respiratory tract, before screening * Use of prohibited medications * Having been on other investigational drug/device studies in the last 30 days prior to screening * Known or highly suspected substance abuse