The purpose of this study is to determine whether Remote Ischemic Perconditioning is effective on Acute kidney injury in adult valve replacement.
Methods: Patients meeting the requirement will be randomized into 2 groups: the treatment group consisted of three 5-minute cycles left lower limb ischemia, induced by inflating a blood pressure cuff on the lower limb to 600 mmHg with an intervening 5 minutes of reperfusion, during which time the cuff was deflate; the control group consisted of placing an uninflated cuff on the left lower limb for 30 minutes. The postconditioning protocol was applied after the aortic cross-clamping. The clinical data of inotropes requirement, drainage, ventilation and intensive care time will be recorded. Venous blood samples will be taken perioperatively for detecting concentration of troponin I (cTnI), Myocardial enzyme, Renal function, Cystatin c, and High-sensitivity c-reactive protein(HS-CRP).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
90
the treatment group consisted of three 4-minute cycles left lower limb ischemia,induced by inflating a blood pressure cuff on the lower limb to 600 mmHg with an intervening 4 minutes of reperfusion ,during which time the cuff was deflate;the control group consisted of placing an uninflated cuff on the left lower limb for 24 minutes.The postconditioning protocol was applied after the aortic cross-clamping.
Central South University
Changsha, Hunan, China
RECRUITINGRenal function
Time frame: within the first 48h after cardiac surgery
concentration of troponin I (cTnI)
Time frame: within 48h after cardiac surgery
Myocardial enzyme
Time frame: within 48h after cardiac surgery
Cystatin C
Time frame: within 48h after cardiac surgery
High-sensitivity c-reactive protein(HS-CRP)
Time frame: within 48h after cardiac surgery
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