Multimodal Assessment of Neurobiological Markers for Psychiatric Disorders

Inclusion Criteria for patients: * DSM-IV-TR diagnosis of MDD or an anxiety disorder (excluding PTSD, specific phobias, and bipolar disorder) by a structured clinical interview (SCID) * aged 18 to 50 years * drug-free within the last three months prior inclusion * willingness and competence to sign the informed consent form Inclusion Criteria for remitted subjects: * a previous DSM-IV-TR diagnosis of MDD or an anxiety disorder (excluding PTSD, specific phobias, and bipolar disorder) but no symptoms at present, determined by SCID * aged 18-50 years * drug-free within the last three months prior inclusion * willingness and competence to sign the informed consent form Inclusion Criteria for healthy control subjects: * Inclusion criteria for healthy control subjects are * willingness and competence to sign the informed consent form * aged 18-50 years * drug-free Exclusion Criteria: * concomitant major internal or neurological illness * concomitant psychiatric disorders (except depression and anxiety for patients, excluding PTSD, claustrophobia and bipolar disorder) * ingestion of any antipsychotic, antidepressant, or anti-anxiety agent within the last three months prior to the screening visit * current substance abuse * failure to comply with the study protocol or to follow the instructions of the investigating team