Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon

Inclusion Criteria: * Patients of any ethnic group, both sexes and aged at least 18 years and a maximum of 65 years * Women and men of childbearing age who agree to use acceptable contraception throughout the study. * Be patient with chronic venous insufficiency of lower limbs varicose comDiagnostico clinical CEAP 0-3 by CEAP * Presence of at least 23 symptoms (pain, heaviness and discomfort, symptoms of heat and burning sensation in the legs) in the lower limbs, with a score equal to or greater than 4, as measured by visual analog scale * Being the 7 days without any medication or treatment related to the venous system. * Patients able to make proper use of medication * Patients who consent to participate in the study by signing the Instrument of Consent. Exclusion Criteria: * Pregnant or breastfeeding women * Women who are breastfeeding * Women and men of childbearing age who do not accept to use acceptable contraception throughout the study * Patients under 18 or over 65 years * Patients with a history of hypersensitivity to any component of the formula * Presence of signs and symptoms of different conditions of venous disease to justify the pain or swelling * Use of elastic compression in the last two weeks * Venous obstruction of the lower limbs * Patients who have previously used or Venaflon Daflon and did not benefit; * Deep vein thrombosis in the last 6 months before entering the study; * Use of diuretics in the last 4 weeks * Previous venous surgery * Patients with renal and liver failure * Patients with gastritis or gastric ulcer * Patients with blood clotting disorders * Any condition which in the opinion of the physician researcher is significant and can make the patient unsuitable for study or you can place it under additional risk