Comparison of TIVA (Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing Postoperative Nausea and Vomiting

Incheon St.Mary's Hospital100 enrolled

Overview

A total intravenous anesthesia (TIVA) is a useful anesthetic technique that reduces the incidence of postoperative nausea and vomiting (PONV). Investigator hypothesized the incidence of PONV can be further reduced when palonosetron is added to TIVA.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

100

Conditions

Postoperative Nausea and Vomiting

Interventions

Total intravenous anesthesiaDRUG

Total intravenous anesthesia plus normal saline 1.5 ml immediately before induction of anesthesia

Total intravenous anesthesia plus palonosetronDRUG

Total intravenous anesthesia plus palonosetron 0.075 mg(1.5 ml)immediately before induction of anesthesia

Eligibility

Sex: FEMALEMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA Physical Status 1 or 2 * Elective gynaecological laparoscopic surgery of ≥ 1h duration Exclusion Criteria: * Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation * Vomiting or retching in the 24 h preceding surgery * Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry * Ongoing vomiting from gastrointestinal disease

Locations (1)

Incheon St. Mary's hospital

Incheon, South Korea

Outcomes

Primary Outcomes

Incidence of postoperative nausea and vomiting

Time frame: For 24 hours after surgery

Secondary Outcomes

Severity of nausea

Time frame: For 24 hours after surgery

Data from ClinicalTrials.gov

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