This is a retrospective analysis of a homogeneous cohort of patients with relapsed/refractory HL that received IGEV scheme as induction therapy to HDCT and AHSCT for reassess the most common prognostic factors and try to identify a prognostic score with clinical and therapeutic relevance by using 6 clinical tools: 1. B symptoms(yes/no) 2. relapse in previously irradiated areas(yes/no) 3. Ann Arbor Stage (III/IV vs I/II) 4. disease status at accrual (refractory vs relapsed) 5. Early relapse within 12 months of Complete Response (CR) versus late relapse after Complete Response (CR) lasting \> l2 months", 6. extranodal involvement (yes/no).
Study Type
OBSERVATIONAL
Enrollment
495
Istituto Oncologico del Mediterraneo
Catania, Catania, Italy
Policlinico Maggiore
Milan, Italy, Italy
Ospedale San Gennaro
Napoli, Italy, Italy
Azienda Ospedaliera V. Cervello
Palermo, Italy, Italy
Azienda Ospedaliera "Bianchi Melacrino Morelli"
Reggio Calabria, Italy, Italy
Presidio Ospedaliero - Unità Complessa Ematologia
Treviso, Italy, Italy
Ematologia e Trapianto IRCCS, Istituto Nazionale dei Tumori
Milan, Milano, Italy
SCDU Ematologia, AOU Maggiore della Carità
Novara, Novara, Italy
Ospedale dell'Angelo
Mestre, VE, Italy
A.O.SS. Biagio, Antonio e Cesare Arrigo
Alessandria, Italy
...and 30 more locations
The prognostic score will be defined taking into account Overall Survival (OS).
Surviving patents will be censored at the date of last known to be alive.
Time frame: 4 years
To evaluate the defined prognostic score in terms of Progression Free Survival (PFS)
response rate in terms of Complete Response (CR) response rate in terms of Overall Response Rate (ORR) To validate the prognostic scores in terms of PFS and in terms OS
Time frame: 4 years
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