The aim of this study is the comparison between the effects of supplementation with omega-3 or placebo for 10 weeks in type 2 diabetics
Adipose tissue is recognized as an important endocrine organ in human. Not only it has function of storing unlimited energy but also its secretory roles is subject to intense research in recent years. Acylation stimulating protein(ASP), Retinol-binding protein 4 (RBP4) and lipocalin-2 (LCN2) are circulating adipokines elevated in diabetes. C5L2 is a G-protein-coupled receptor. activation of C5L2 by ASP, has been shown. Fatty acids may influence the expression of adipokines. Epidemiological studies showed that omega-3 reduce the development of insulin resistance and diabetes. Because fatty acids are the main component of adipose tissue, it is essential interest to clarify the biological effects of omega-3 on the expression of relevant adipokines.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
20
Tehran University of Medical Sciences
Tehran, Tehran Province, Iran
serum total cholesterol
Time frame: change from baseline at 10 weeks
serum High-density lipoprotein (HDL) cholesterol
Time frame: change from baseline at 10 weeks
serum Low-density lipoprotein (LDL) cholesterol
Time frame: change from baseline at 10 weeks
serum triglycerides (TG) level
Time frame: change from baseline at 10 weeks
postprandial triglycerides
Time frame: change from baseline at 10 weeks
complete blood count(CBC)
Time frame: change from baseline at 10 weeks
fasting plasma glucose(FPG)
Time frame: change from baseline at 10 weeks
Glycated hemoglobin (Hb A1c)
Time frame: change from baseline at 10 weeks
acylation stimulating protein (ASP)
Time frame: change from baseline at 10 weeks
lipocalin-2 (LCN2)
Time frame: change from baseline at 10 weeks
Retinol-binding protein 4 (RBP4)
Time frame: change from baseline at 10 weeks
non-esterified fatty acids (NEFA)
Time frame: change from baseline at 10 weeks
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insulin
Time frame: change from baseline at 10 weeks
postprandial ASP
Time frame: chage from baseline at 10 weeks
gene expression of C5L2
Time frame: change from baseline at 10 weeks