A Study for Moderate Osteoarthritis of the Knee

Inclusion Criteria: * Ambulatory male or female patients aged 30-65 years, and diagnosed of OA of the knee according to the ACR clinical and radiographic criteria * ARA functional class II or III * Kellgren Lawrence radiological severity of Grade II, Grade III OA knee * Maximal OA pain on movement, as measured on a 0-100 Visual analog scale (VAS) should be more than 40 and less than 80 in the previous 24 hrs at screening and baseline visits Exclusion Criteria: * Conditions that can mimic OA knee pain, E.g. rheumatoid arthritis, systemic lupus erythematosus, gout, psoriatic arthritis, pseudo gout or pain due to malignant disease * BMI \>35 kg/m2 * Indication of surgery for OA knee * Arthroscopy of either knee in the past year * Use of analgesics or any other symptom-relieving medication within 7 days of screening * Use of systemic steroids or herbal medication for OA within 4 weeks of screening * Use of Vit. D3 injections, Glucosamine sulphate, Chondroitin sulphate, Diacerin, Alendronate in the past 3 months * Administration of intra-articular steroids in the past 3 month or hyaluronic acid in the last 9 months * History of osteoporotic/ osteoarthritic fractures within the past 6 months * Pregnant or lactating women or women with inadequate contraceptive measures * Evidence or clinical suspicion of any major medical conditions (E.g. uncontrolled diabetes mellitus, uncontrolled hypertension, cardiovascular disease, thyroid, hepatic, renal dysfunction) * Presence of any clinically significant laboratory anomaly * Known cases of AIDS (HIV positive) * History of Coronary Angioplasty/CABG within the past 2 years * Moderate to severe peripheral neuropathy or other neurological disorders * Alcohol abuse, medication or drug dependence * Concurrent or previous participation in a clinical study within previous 6 weeks