Absorption and Metabolism of Olive Leaf Extract and Its Effect on Vascular Reactivity and Cytokine Concentrations

Inclusion Criteria: * 19-40 years, non-smokers, able to swallow capsules, have a Body Mass Index (BMI) of 18.5-30, have a normal liver function and haematology and a max alcohol intake of \<21 units/week Exclusion Criteria: * Those who suffer from any form of disease, including endocrine disease, liver disease, diabetes mellitus, myocardial infarction, blood clotting disorder, reproductive disorder, gastrointestinal disease or a chronic gastrointestinal disorder. * Individuals who are vegetarian, have dietary restrictions or on a weight reducing diet will not be recruited. * Subjects who have been taking antibiotics in previous 3 months before study will not be included in the study * Females who may be pregnant, or if of childbearing potential and are not using effective contraceptive precautions will be excluded. * Blood pressure \> 150/90 mmHg * Haemoglobin \< 125 g/l for male, \< 110 g/l for female * Gamma GT (liver enzymes) \> 80 IU/l * Cholesterol \> 6.5 mmol/l * Had suffered a myocardial infarction or stroke in the previous 12 months * On any lipid-modifying medication * On any medication affecting blood clotting * Individuals taking vitamin and/or fish oil supplements