AZD5069 Neutrophil Function Study

Inclusion Criteria: * Healthy Caucasian male or post-menopausal/surgical sterile females, aged 18 to 45 years inclusive at screening * Only women of non-childbearing potential are included in the study, ie, women who are permanently or surgically sterilised or post-menopausal * Non-smokers or ex-smokers with no smoking history the last 12 months prior to Visit 1 and a smoking history of less than 10 pack years (1 pack year = tobacco consumption corresponding to 20 cigarettes smoked per day for 1 year) at screening * Body mass index (BMI) \>18 kg/m2 and ≤30 kg/m2 and a minimum weight of 50 kg Exclusion Criteria: * Subjects with a history of or active or latent tuberculosis (TB), or close contact with anybody with active TB * Subjects with a history of malignancy or neoplastic disease (except successfully treated basal or squamous cell carcinoma of the skin) * Subjects who are pyrexial with a body temperature of greater than 37.7 C at Visit 2, or as judged by the Investigator * Alanine aminotransferase (ALT)/aspartate aminotransferase (AST) level ≥1.5 x upper limit of normal (ULN) at screening (Visit 2) * Peripheral blood neutrophils above or below the laboratory reference range at screening (Visit 2) hsCRP above the upper limit of the laboratory reference range at Visit 2