A Dose Evaluation Study of the Effect of Plug Placement on the Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Mati Therapeutics Inc.77 enrolled

Overview

The purpose of this study is to determine the effect of plug placement on the efficacy, safety and duration of effect of the L-PPDS (latanoprost punctal plug delivery system).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Glaucoma Ocular Hypertension (OH)

Interventions

Latanoprost-PPDSDRUG

Sustained release for 12 weeks

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female at least 18 years old * Diagnosis of bilateral open angle glaucoma or ocular hypertension * Unmedicated IOP must be ≥22mm Hg Exclusion Criteria: * Any significant vision loss in the last year * No contact lens use for the length of the study * Abnormal eye lids, eye infection or diseases to the eye * Recent eye surgery * Uncontrolled medical conditions

Locations (11)

Vold Vision

Springdale, Arkansas, United States

Glaucoma Consultants of Colorado, PC

Denver, Colorado, United States

Danbury Eye Physicians & Surgeons

Danbury, Connecticut, United States

Outcomes

Primary Outcomes

IOP change from baseline

Time frame: 12 weeks to baseline

Data from ClinicalTrials.gov

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