Comparative Study of Photodynamic Therapy vs. CO2 Laser Therapy in Treatment of Actinic Keratoses

Ruhr University of Bochum21 enrolled

Overview

The purpose of this study is to determine whether photodynamic therapy or CO2 laser therapy is superior in the treatment of actinic keratoses with respect to efficacy and side effects.

Ablative laser therapy and photodynamic therapy are widely used and accepted therapeutic methods to treat multiple actinic keratoses, yet comparative studies are rare. The purpose of this study is to compare both treatments intraindividually with respect to treatment efficacy and side effects.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Actinic Keratosis

Interventions

ablative CO2 laser therapyPROCEDURE

CO2 laser therapy

photodynamic therapyPROCEDURE

Treatment with 5-ALA cream, application time at least 4 h, red light radiation with 76 J/cm²

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * men and women with clinical and histological diagnosed, symmetrical distributed actinic keratoses * at least 2 actinic keratoses, on each of both treatment areas at least one * Patients must be 18 years or older. Exclusion Criteria: * Age 17 years or younger * lack of patient's informed consent for any of the two treatments * contraindication for Co2 therapy or for photodynamic therapy * skin infection in the treatment area

Locations (1)

Department of Dermatology, Venereology and Allergology, Ruhr University

Bochum, Germany

Outcomes

Primary Outcomes

Number of actinic keratoses 3 months after treatment

Time frame: 3 months

Secondary Outcomes

Histologic features

Time frame: 1 month after therapy

Epidermal thickness in optical coherence tomography

Time frame: 1 month after therapy

Data from ClinicalTrials.gov

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