The purpose of this study is to determine whether preemptive nucleoside analogue therapy or regular virologic monitoring is the preferred method in management patients with prior exposure to hepatitis B vius (HBV) and undergoing hematopoietic stem cell transplantation (HSCT).
Occult hepatitis B virus (HBV) reactivation has been documented in bone marrow transplantation recipients who are hepatitis B surface antigen (HBsAg)-negative but with serologic evidence of prior exposure to HBV. However detailed prospective studies documenting the incidence of reactivation and the virologic and serologic kinetics of reactivation are lacking. The investigators prospective study proposes to follow-up 50 such bone marrow transplant recipients with all serologic and virologic parameters monitored every 4 weeks. Patients with detectable HBV DNA will be started on nucleoside analogue therapy. The optimal method and duration of monitoring will also be determined from our study.
Study Type
OBSERVATIONAL
Enrollment
69
Department of Medicine, The University of Hong Kong, Queen Mary Hospital
Hong Kong, Hong Kong
HBV reactivation (defined as detectable HBV DNA >20 IU/mL)
From date of hematopoietic stem cell transplantation (HSCT) to 2 years after HSCT.
Time frame: 2 years
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