Previous research regarding the use of phenylephrine has excluded obese subjects (BMI \>35). This subgroup of patients represents a large portion of the obstetric patient population locally and nationally. It is unclear whether previous research should be extrapolated to the obese patient population. This study is being done to compare the incidence of hypotension, intraoperative nausea and vomiting, and neonatal acidosis between obese patients who receive a prophylactic phenylephrine infusion versus those who receive phenylephrine boluses for the treatment of established hypotension. This study will help us determine whether using a phenylephrine infusion or a phenylephrine bolus is the best way to prevent/treat spinal induced hypotension during cesarean deliveries in obese patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
178
10 ml of 100mcg/ml phenylephrine and placebo infusion
60ml infusion of 100mcg/ml phenylephrine and placebo bolus
Duke University Medical Center
Durham, North Carolina, United States
IWK Health Centre
Halifax, Nova Scotia, Canada
Incidence of Nausea and Vomiting
Time frame: intraoperative 2-3 hours
Incidence of Nausea and Vomiting
Time frame: 2 hrs postoperative
Incidence of Nausea and Vomiting
Time frame: 24hrs postoperative
Incidence of Hypotension
Time frame: intraoperative - predelivery
Incidence of Hypotension
Time frame: intraoperative - postdelivery
Neonatal Acidosis
Time frame: intraoperative
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