Efficacy and Safety of Palonosetron Hydrochloride in the Prevention of Nausea and Vomiting

Inclusion Criteria: 1. Patients candidates to a chemotherapy treatment, with histologically or cytologically confirmed malignant disease; 2. The concrete chemotherapy plan does not limited, group I (Highly Emetogenic Chemotherapy), group II (Moderately Emetogenic Chemotherapy); 3. Male or female aged 18-75 years, ECOG≤2, estimates survival time≥3 months; 4. WBC≥3.0×109/L, ANC≥1.5×109/L, PLT≥80×109/L, total bilirubin≤1.5×ULN(Normal value upper limit), AST and ALT≤2.5×ULN(With transferability liver cancer≤5×ULN), Cr and BUN≤1.5×ULN, electrolyte and electrocardiogram are normal, conforms to the chemotherapy adaptation; 5. Patients have been apart from the previous chemotherapy to finish above 2 weeks (including 2 weeks); 6. Patients that voluntarily sign the consent form. Exclusion Criteria: 1. Pregnancy, or patients during breast feeding; 2. Patients have accepted any radiotherapy during the experimental period; 3. Gastric outlet or intestinal obstruction; 4. Patients have serious heart diseases, liver kidney diseases, or metabolism function disorder; 5. Patients have epilepsy, or have been used psychotropic drug and calm drug; 6. Received any drugs with potential anti-emetic efficacy, or experienced any vomiting, nausea or retching in the 24 hours prior to chemotherapy; 7. Patients with transferability brain tumor, have vomiting caused by skull high pressure, or can not speak sickness situation and adverse reactions by self; 8. Patients have known hypersensitivity to 5-HT3 antagonists; 9. Patients have chemotherapy contraindications; 10. Patients are participating, or have participated in other Clinical studies of new drugs within 2 weeks.