The Effect of Genetic Polymorphism on Interactions of Clopidogrel and Cilostazol in Healthy Volunteers

Inje University28 enrolled

Overview

The aim of this study is to investigate the effects of genetic polymorphisms on pharmacokinetic and pharmacodynamic interactions of clopidogrel and cilostazol in Korean healthy adult volunteers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Interaction

Interventions

ClopidogrelDRUG

single oral administration of 300mg of clopidogrel

CilostazolDRUG

single oral administration of 100mg cilostazol

Clopidogrel/CilostazolDRUG

single oral administration of 300mg clopidogrel and 100mg cilostazol

Eligibility

Sex: MALEMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy male subject whose CYP2C19 genotype was determined Exclusion Criteria: * Subject who has abnormal laboratory test results

Outcomes

Primary Outcomes

Maximum concentration(Cmax), Area under the concentration(AUC), Inhibition of platelet aggregation(IPA)

9 or 11 point blood sampling according to the interventions

Time frame: up to 24 hours

Data from ClinicalTrials.gov

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